- **Biomarkers without clear interpretation:** A molecular result may require clinical context to distinguish actionable, uncertain, or non-relevant findings for the tumour.

When cancer progresses, some families seek to review resistance mechanisms and alternatives subject to evidence and indication.

Eligibility may depend on tumour type, markers, prior treatments, autoimmune conditions, and the patient's overall condition before making decisions.

An international review may explore whether repeating, expanding, or reinterpreting analyses is worthwhile, without assuming they will change clinical management.

Comparing a documented proposal helps distinguish real medical possibilities from messages that exaggerate innovation or results before making decisions.

The value may lie in ordering tests, decisions, and timelines, not solely in identifying a potential drug before making decisions.

- **Patient with a molecular profile:** Individuals with genomic results who need additional clinical interpretation and specific questions about possible options, for individual physician evaluation.

Cases that have received several lines and seek a prudent review of biomarkers, resistance, and subsequent strategies, for individual physician evaluation.

Patients with a reported alteration who need to confirm relevance, evidence, indication, and availability before making decisions, for individual physician evaluation.

Individuals who want to understand predictive markers, immunological risks, and medical reasons for indicating or ruling out this strategy, for individual physician evaluation.

Cases where it could be evaluated whether tissue, quality control, methodology, or clinical information is missing for interpreting results, for individual physician evaluation.

Families seeking a structured comparison of evidence, requirements, timelines, costs, and local follow-up, for individual physician evaluation.

- **Biomarker reinterpretation:** The clinical relevance of mutations, amplifications, fusions, protein expression, and other available results may be reviewed, according to individual physician evaluation.

When medically justified, an additional test and its limits for generating useful clinical decisions may be explored, according to individual physician evaluation.

Specialists may review evidence, line of treatment, contraindications, and availability for a potentially actionable alteration, according to individual physician evaluation.

Appropriateness may be analyzed based on tumour, PD-L1, MSI, TMB, autoimmune history, and prior treatments, among other factors, according to individual physician evaluation.

The team may study progression patterns and subsequent outcomes to raise questions about mechanisms and possible sequences, according to individual physician evaluation.

Some combinations may be discussed only when evidence, indication, specialized supervision, and appropriate institutional access exist, according to individual physician evaluation.

- **Case reception:** We collect diagnosis, goals, history, travel restrictions, and questions via form, email, WhatsApp, or document upload, with scope agreed in advance.

We review legibility, dates, coherence, and missing items to avoid presenting an incomplete record to an institution, with scope agreed in advance.

We translate the priority documents that the specialist or hospital needs to understand the case, with scope agreed in advance.

We prepare a concise timeline with findings, interventions, response, current medications, and still-pending decisions, with scope agreed in advance.

We research potentially relevant departments, institutions, and specialists without claiming formal collaboration or guaranteed access, with scope agreed in advance.

We deliver possible pathways, requirements, questions, limits, steps, and logistical considerations adapted to the information received, with scope agreed in advance.

We can organize a paid consultation with a Chinese precision oncology specialist, subject to acceptance, availability, documentation, and scheduling.

If the case advances, we coordinate appointments, interpretation, admission, mobility, documentation, and post-care support according to the contracted service, with scope agreed in advance.